Hofmann 重排(降解)

    酰胺用溴(或氯)在碱性条件下处理转变为少一个碳原子的伯胺:

反应机理

反应实例

参考文献

[1] A. W. Hofrnann. Ber., 1881, 14, 272.

[2] A. W. Hofmann, Ber., 1882, 15, 407, 752, 762 ; 1884, 17, 1406; 1885, 18, 2734.

[3] E. C. Franklin, Chem. Revs., 1934, 14, 219.

[4] E. S. Wallis and J. F. Lane, Organic Reactions, 1949, 3, 267.

[5] D. E. Applequist and J. D. Roberts, Chem. Revs., 1954, 54, 1083.

[6] V. Franzen, Reaktionsmechandsmen ,  Heidelberg, 1954, 1, 57.